Description
Description
Nano Hydroxyapatite is a calcium-phosphate mineral with the same fundamental crystal chemistry as the principal inorganic phase of tooth enamel and dentin. At nanoscale dimensions, the high surface area and fine particle size make the material useful in advanced toothpaste and oral-care systems designed around mineral deposition, surface smoothing, and enamel-mimetic technology.
Chemical & Technical Profile
| INCI / Identity | Hydroxyapatite |
|---|---|
| CAS No. | 1306-06-5 |
| Molecular Formula | Ca10(PO4)6(OH)2 |
| Molecular Weight | 1004.62 g/mol |
| Physical Form | White fine powder |
| Solubility | Practically insoluble in water; dispersible as a mineral particulate |
| Functional Category | Calcium-phosphate oral-care mineral / abrasive-polishing active |
Mechanism of Action / Technical Function
Hydroxyapatite does not function through a receptor-mediated mechanism. Its effect is interfacial and mineralogical: calcium-phosphate particles can adsorb to tooth surfaces, occupy microscopic irregularities, and provide a mineral source compatible with enamel-like apatite. Particle size, crystallinity, surface area, and dispersion determine practical deposition behavior more than nominal chemical formula alone.
Formulation Guidelines
Disperse gradually into the aqueous/humectant phase using sufficient shear to break soft agglomerates without creating excessive aeration. Wetting with glycerin, sorbitol, or another compatible humectant can improve incorporation. Rheology must be designed to suspend the mineral and prevent sedimentation. Avoid uncontrolled addition to highly viscous toothpaste bases. Evaluate interaction with fluoride salts, surfactants, and other calcium-reactive ingredients because ion exchange or complexation can change product performance.
Compatibility & Stability
Monitor particle settling, viscosity, syneresis, abrasive behavior, pH, and package compatibility. Particle-size distribution is a critical quality attribute. Oral-care prototypes should be tested for cleaning, surface interaction, and sensory performance using application-relevant methods.
R&D, Scale-Up & Quality Control
Critical quality attributes for Nano Hydroxyapatite Powder include particle appearance, dispersion quality, pH, and particle-size consistency where available. The production record should fix hydroxyapatite wetting, charging rate, and the shear used before final toothpaste thickening; otherwise a chemically correct formula can still show batch-to-batch physical variation.
Lot Specifications & Documentation
Key results from the Certificate of Analysis for the current lot (production lot 2026-06-09, manufacturer grade HAP01-60nm). Values are reported by the manufacturer.
| INCI name | Hydroxyapatite |
|---|---|
| CAS No. | 1306-06-5 |
| Appearance | White powder |
| Particle size | Average 60 nm, within ±15 nm (conforms) |
| Morphology | Needle / rod shaped |
| Purity (HAP content) | 96% (specification ≥ 96%) |
| Ca/P molar ratio | 1.667 (1.66–1.71) |
| Loss on drying (105 °C) | 0.7% (≤ 3%) |
| Heavy metals | Pb 0.168, Hg 0.355, As 0.612, Cd 0.092 mg/kg; total 15 mg/kg (≤ 30 mg/kg) |
| Identity | IR spectrum conforms |
| SKU | PI-RM-0077 |
Documentation
- Certificate of Analysis (COA) for the lot shipped: included with your order. After payment, download it from My Account › Downloads or from the link in your order email. Need it before buying? Email info@pureingredients.us.
- Safety Data Sheet (SDS) and Technical Data Sheet: available on request at info@pureingredients.us.
For cosmetic formulation use only. Not for direct application to skin.
Packaging, Shipping & Storage
Supplied in a sealed aluminum pouch. Store tightly closed, dry, and protected from humidity. Prevent airborne dust during weighing and minimize moisture pickup.
Estimated Delivery: 10–15 Business Days
Applications
Toothpaste, polishing gels, enamel-care products, desensitizing-oriented oral-care concepts, and professional mineral-based dental formulations.
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