Description
Description
WS-23 is a synthetic carboxamide cooling agent that provides a clean, relatively low-odor cooling sensation without the strong mint character of menthol. It is used in scalp, body, oral-adjacent, and sensory cosmetic systems where cooling should be separated from fragrance identity.
Chemical & Technical Profile
| INCI / Identity | 2-Isopropyl-N,2,3-trimethylbutyramide (WS-23) |
|---|---|
| CAS No. | 51115-67-4 |
| Molecular Formula | C10H21NO |
| Molecular Weight | 171.28 g/mol |
| Physical Form | White crystalline powder |
| Solubility | Low water solubility; soluble in alcohols, glycols, oils, and flavor/fragrance carriers |
| Functional Category | Non-menthol cooling sensate |
Mechanism of Action / Technical Function
WS-23 activates cold-sensitive TRPM8 sensory receptors in peripheral nerve endings, generating a cooling perception without actual reduction in tissue temperature. The mechanism is sensory receptor agonism rather than evaporation. Its onset and profile differ from menthol and from other WS-series coolants, allowing tailored sensory design.
Formulation Guidelines
Pre-dissolve in ethanol, propylene glycol, suitable glycols, fragrance oils, or another compatible carrier. Do not add crystalline WS-23 directly to water. Introduce the concentrate during cool-down and confirm complete solubility after dilution. Excessive concentration can create unpleasant cold/burning sensation; sensory evaluation should be controlled and performed at conservative levels.
Compatibility & Stability
Monitor crystallization, clarity, odor, and sensory consistency. Low-temperature storage can reveal marginal solvent capacity. Volatile carrier loss can also trigger recrystallization in open packaging. A retained reference and defined accelerated-stability protocol should be used so visual and functional changes can be interpreted consistently across production lots.
R&D, Scale-Up & Quality Control
For WS-23 Cooling Agent, incoming and in-process QC should control WS-23 identity, crystal-free solution, odor neutrality, and sensory intensity. Pilot transfer should lock pre-solvent choice, cool-down dilution, and final carrier composition, because these variables directly influence reproducibility. Release the formulation only after no recrystallization develops and the cooling profile remains consistent across retained batches.
Packaging, Shipping & Storage
Supplied in a sealed aluminum pouch. Store tightly closed, cool, dry, and protected from humidity and heat.
Applications
Scalp tonics, shampoos, body gels, after-sun cosmetics, foot care, sports body products, and cooling sensory formulations.
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