Description
Description
Acetyl Hexapeptide-8 is a synthetic six-amino-acid peptide derived from a SNAP-25-related sequence and widely used in premium expression-line and age-support formulations. Its small peptide structure and aqueous compatibility make it suitable for serums and light emulsions, but biological activity depends on maintaining peptide integrity during processing and storage.
Chemical & Technical Profile
| INCI / Identity | Acetyl Hexapeptide-8 |
|---|---|
| CAS No. | 616204-22-9 |
| Molecular Formula | C34H60N14O12S |
| Molecular Weight | 889.0 g/mol |
| Physical Form | White to off-white powder |
| Solubility | Water-soluble |
| Functional Category | Neurotransmission-modulating cosmetic peptide |
Mechanism of Action / Technical Function
The peptide is designed to interfere with formation of the SNARE protein complex involved in vesicle docking and acetylcholine release at neuromuscular junctions. The activity is sequence-dependent; degradation or hydrolysis of the peptide materially reduces functional performance.
Formulation Guidelines
Dissolve in purified water or a cool aqueous premix and add below approximately 40°C whenever practical. Avoid prolonged heating, strongly acidic or alkaline systems, aggressive oxidants, and high concentrations of proteolytic botanical extracts. Incorporate after high-shear emulsification rather than exposing the peptide to unnecessary mechanical stress. In multi-peptide serums, control total dissolved solids and preservative compatibility to prevent viscosity loss or haze.
Compatibility & Stability
Monitor pH, color, odor, clarity, peptide integrity where analytical testing is available, and microbial stability. Avoid repeated freeze-thaw cycles of concentrated solutions. Transparent formulas should be evaluated for long-term color and haze development.
R&D, Scale-Up & Quality Control
Acetyl Hexapeptide-8 Powder should be qualified against peptide identity, solution clarity, pH, and microbial quality, using a retained reference where visual change is relevant. During scale-up, document the cool-down addition temperature, post-addition shear, and preservative exposure and reproduce the laboratory sequence without unplanned thermal or shear exposure.
Packaging, Shipping & Storage
Supplied in a sealed aluminum pouch. Store tightly closed, cool, dry, and protected from light and humidity. Refrigerated storage is preferred for long-term preservation of peptide quality.
Estimated Delivery: 10–15 Business Days
Applications
Facial serums, eye-area products, expression-line treatments, lightweight emulsions, gel-creams, and advanced multi-peptide systems.
Related Ingredients
GHK-Cu / Copper Tripeptide-1 • Matrixyl 3000-Type Peptide
Documentation & Use
- Certificate of Analysis (COA) for the lot shipped: available on request at info@pureingredients.us.
- Safety Data Sheet (SDS): available on request.
- SKU: PI-RM-0001
For cosmetic formulation use only. Not for direct application to skin.
Frequently Asked Questions
What is Acetyl Hexapeptide-8?
Acetyl Hexapeptide-8 is a synthetic acetylated six-amino-acid peptide (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2; CAS 616204-22-9; C34H60N14O12S; 889.0 g/mol). It is supplied as a white to off-white, water-soluble powder.
Is it the same as Argireline?
Argireline® is a registered trademark of Lubrizol for its branded Acetyl Hexapeptide-8. This product is a generic Acetyl Hexapeptide-8 with the same INCI name, not the Lubrizol product. The same peptide was previously listed under the INCI name Acetyl Hexapeptide-3.
How do I add it to a formula?
Dissolve it in purified water or a cool aqueous premix and add it below about 40 °C where practical. In emulsions, add it after high-shear emulsification to avoid unnecessary heat and mechanical stress.
Which conditions should I avoid?
Prolonged heating, strongly acidic or alkaline systems, aggressive oxidants and high levels of proteolytic botanical extracts. In multi-peptide serums, watch total dissolved solids and preservative compatibility to avoid haze or viscosity loss.
What use level should I use?
Base the level on the supplier’s technical data and your own finished-product testing. Email info@pureingredients.us for the documentation available for the current lot.
How should I store it?
Keep the sealed aluminum pouch tightly closed in a cool, dry place away from light and humidity. Refrigerated storage is preferred for long-term storage, and repeated freeze-thaw cycles of concentrated solutions should be avoided.
Which sizes are available?
50 g, 100 g, 200 g, 500 g and 1 kg.
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