Description
Description
N-Acetyl Glucosamine (NAG) is an acetylated amino sugar and a structural building block of glycosaminoglycans, including hyaluronic acid. It is used in advanced skin-care systems for hydration support, surface renewal, and tone-evening, particularly in combinations where formulators want a highly water-soluble active with low formulation burden.
Chemical & Technical Profile
| INCI / Identity | N-Acetyl Glucosamine |
|---|---|
| CAS No. | 7512-17-6 |
| Molecular Formula | C8H15NO6 |
| Molecular Weight | 221.21 g/mol |
| Physical Form | White crystalline powder |
| Solubility | Freely soluble in water |
| Functional Category | Amino sugar / skin-conditioning active |
Mechanism of Action / Technical Function
NAG participates in hexosamine biochemistry and can contribute substrate availability for glycosaminoglycan-related pathways. In pigmentation research, it has also been associated with reduced conversion of pro-tyrosinase to active tyrosinase, providing a mechanistic basis for tone-evening applications. Combination studies with niacinamide are especially relevant because the two materials act through complementary pathways rather than simply duplicating one another.
Formulation Guidelines
Dissolve directly into purified water or a concentrated aqueous premix. It can be incorporated into the main water phase or during cool-down depending on the architecture of the formula. Maintain a moderate cosmetic pH and avoid unnecessarily harsh thermal exposure. NAG is compatible with many humectants, niacinamide, hyaluronic-acid systems, and emulsions. In high-solids serums, evaluate the total dissolved-solids load because concentrated amino sugars can affect tack, water activity, and sensory profile.
Compatibility & Stability
Monitor color, clarity, pH, crystallization, and viscosity. Maillard-type browning risk should be considered in systems containing reactive amino compounds and reducing sugars under elevated temperature, although N-acetylation reduces the reactivity compared with free glucosamine. Long hot holds should therefore be avoided.
R&D, Scale-Up & Quality Control
For N-Acetyl Glucosamine Powder, incoming and in-process QC should control identity, solution clarity, pH, and color. Pilot transfer should lock N-acetyl glucosamine dissolution, total aqueous solids, and exposure to prolonged heat, because these variables directly influence reproducibility. Release the formulation only after no crystallization or heat-induced browning develops in the finished system.
Packaging, Shipping & Storage
Supplied in a sealed aluminum pouch. Keep tightly closed, cool, dry, and protected from humidity. Avoid repeated moisture exposure after opening.
Estimated Delivery: 10–15 Business Days
Applications
Hydrating serums, brightening treatments, moisturizers, facial gels, essences, masks, and niacinamide-based multi-active formulations.
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