Description
Pentapeptide-3 Powder is a high-purity cosmetic peptide raw material used in premium skincare formulations targeting the visible appearance of fine lines, expression wrinkles, and skin surface smoothness.
This ingredient is commonly associated with advanced anti-aging cosmetic systems where the goal is to improve the look of facial expression lines, especially in areas such as the forehead, eye contour, and nasolabial region. It is intended for professional cosmetic formulation use and should not be applied directly to the skin without proper formulation.
Pentapeptide-3 is suitable for serums, creams, eye treatments, ampoules, and professional skincare products developed for smoother, more refined, and younger-looking skin.
Technical Information
| Specification | Details |
|---|---|
| INCI Name | Pentapeptide-3 |
| Ingredient Type | Synthetic cosmetic peptide |
| Physical Form | White to off-white powder |
| Cosmetic Function | Skin conditioning; expression-line smoothing support |
| Typical Use Level | Commonly used according to supplier recommendation and formulation design |
| Processing Temperature | Add below 40°C |
| Solubility | Usually incorporated through the water phase or suitable peptide-compatible solvent system |
| Storage | Store tightly sealed in a cool, dry, dark place, protected from moisture and heat |
Note: CAS number, purity, assay method, peptide sequence, and exact recommended dosage should be confirmed from the supplier COA, TDS, and specification sheet before formulation approval.
Key Cosmetic Benefits
Expression Line Smoothing Support
Pentapeptide-3 is used in cosmetic formulations designed to reduce the visible appearance of expression-related lines. It is especially suitable for products targeting areas where facial movement contributes to the appearance of wrinkles.
Smoother-Looking Skin
When properly formulated, Pentapeptide-3 can support a softer and smoother skin appearance. It is commonly used in anti-aging products where surface refinement and improved skin feel are important performance targets.
Advanced Anti-Aging Positioning
Pentapeptide-3 is suitable for premium skincare products positioned around visible wrinkle care, expression-line management, and professional anti-aging cosmetic performance.
Eye and Facial Care Compatibility
Because expression lines are highly visible around the eye contour, forehead, and mouth area, Pentapeptide-3 can be used in specialized eye treatments, facial serums, and targeted wrinkle-care formulations.
Recommended Applications
Pentapeptide-3 Powder can be used in:
- Anti-wrinkle facial serums
- Eye contour treatments
- Anti-aging creams and lotions
- Expression-line smoothing ampoules
- Professional skincare formulations
- Premium facial moisturizers
- OEM and private-label anti-aging products
Recommended Usage
Pentapeptide-3 should be used according to the supplier’s technical data sheet and final formulation requirements. Typical cosmetic peptide systems are usually added at low active levels, depending on peptide purity, dilution form, and final product positioning.
For powder material, formulators should carefully calculate the active peptide concentration and validate the final dosage through stability, compatibility, and safety testing.
Formulation Guidelines
Pre-dissolve or disperse Pentapeptide-3 in a suitable water phase or peptide-compatible solvent system.
Add during the cool-down phase, preferably below 40°C.
Avoid prolonged exposure to high heat.
Avoid extreme pH conditions unless supported by supplier stability data.
Protect the formula from microbial contamination during processing.
Use appropriate preservation systems compatible with peptide-containing formulations.
Confirm compatibility with electrolytes, acids, high-alcohol systems, strong oxidizers, and aggressive surfactant systems before scale-up.
Formulation Considerations
Pentapeptide-3 is a delicate cosmetic peptide and should be handled as a high-value active raw material. During formulation development, the R&D team should evaluate solubility, clarity, peptide stability, preservative compatibility, pH drift, color change, odor development, and long-term storage behavior.
For commercial production, the ingredient should be added at low temperature under gentle mixing. Excessive heat, uncontrolled pH, poor microbial control, or unsuitable solvent systems may reduce performance or affect finished product stability.
Mechanism of Action
At cosmetic-use level, Pentapeptide-3 is used to support the visible smoothing of expression lines. It is commonly positioned as an advanced peptide for reducing the appearance of wrinkles associated with repetitive facial movement.
All claims should remain cosmetic and appearance-based. The ingredient is not intended to affect neuromuscular function in a medical or pharmaceutical sense and should not be presented as an injectable treatment alternative.

Suitable claims:
- Helps reduce the visible appearance of expression lines
- Supports smoother-looking skin
- Helps improve the appearance of fine lines
- Supports a more refined skin texture
- Ideal for advanced anti-aging skincare
- Suitable for eye contour and facial wrinkle-care formulations
Avoid or review carefully:
- Botox-like effect
- Muscle relaxant treatment
- Treats wrinkles
- Clinically reverses aging
- Stimulates collagen production
- Repairs skin structure
- Medical or therapeutic anti-wrinkle claims
Regulatory & Compliance Notes
Pentapeptide-3 is listed as a cosmetic peptide ingredient and is used in topical skincare formulations. Final product compliance depends on the target market, product category, use level, safety assessment, claim wording, and supporting documentation.
Brands and formulators should review local cosmetic regulations before commercialization, including EU, FDA, ASEAN, GCC, and other applicable market requirements.
This raw material is not intended for oral, injectable, pharmaceutical, or direct consumer use.
Why Choose Our Pentapeptide-3 Powder?
We supply cosmetic-grade Pentapeptide-3 Powder for professional skincare formulation, OEM manufacturing, private-label development, and advanced cosmetic R&D laboratories.
Our support includes:
- High-purity cosmetic peptide raw material
- Batch-to-batch quality consistency
- Technical formulation support
- Regulatory documentation assistance
- Stability and scale-up troubleshooting guidance
Pentapeptide-3 Powder is suitable for brands developing premium anti-aging, wrinkle-care, eye contour, and professional skincare products.
Shipping Information
Free worldwide shipping.
Estimated delivery time: 10–15 business days, depending on destination, customs clearance procedures, and local logistics conditions.






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