Description
Description
Acetyl Hexapeptide-8 is a synthetic six-amino-acid peptide derived from a SNAP-25-related sequence and widely used in premium expression-line and age-support formulations. Its small peptide structure and aqueous compatibility make it suitable for serums and light emulsions, but biological activity depends on maintaining peptide integrity during processing and storage.
Chemical & Technical Profile
| INCI / Identity | Acetyl Hexapeptide-8 |
|---|---|
| CAS No. | 616204-22-9 |
| Molecular Formula | C34H60N14O12S |
| Molecular Weight | 889.0 g/mol |
| Physical Form | White to off-white powder |
| Solubility | Water-soluble |
| Functional Category | Neurotransmission-modulating cosmetic peptide |
Mechanism of Action / Technical Function
The peptide is designed to interfere with formation of the SNARE protein complex involved in vesicle docking and acetylcholine release at neuromuscular junctions. In topical cosmetic positioning, this mechanism is interpreted as modulation of signaling associated with repetitive facial expression rather than pharmacological paralysis. The activity is sequence-dependent; degradation or hydrolysis of the peptide materially reduces functional performance.
Formulation Guidelines
Dissolve in purified water or a cool aqueous premix and add below approximately 40°C whenever practical. Avoid prolonged heating, strongly acidic or alkaline systems, aggressive oxidants, and high concentrations of proteolytic botanical extracts. Incorporate after high-shear emulsification rather than exposing the peptide to unnecessary mechanical stress. In multi-peptide serums, control total dissolved solids and preservative compatibility to prevent viscosity loss or haze.
Compatibility & Stability
Monitor pH, color, odor, clarity, peptide integrity where analytical testing is available, and microbial stability. Avoid repeated freeze-thaw cycles of concentrated solutions. Transparent formulas should be evaluated for long-term color and haze development.
R&D, Scale-Up & Quality Control
Acetyl Hexapeptide-8 Powder should be qualified against peptide identity, solution clarity, pH, and microbial quality, using a retained reference where visual change is relevant. During scale-up, document the cool-down addition temperature, post-addition shear, and preservative exposure and reproduce the laboratory sequence without unplanned thermal or shear exposure.
Packaging, Shipping & Storage
Supplied in a sealed aluminum pouch. Store tightly closed, cool, dry, and protected from light and humidity. Refrigerated storage is preferred for long-term preservation of peptide quality.
Applications
Facial serums, eye-area products, expression-line treatments, lightweight emulsions, gel-creams, and advanced multi-peptide systems.
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