Description
Description
Dimethyl Isosorbide (DMI) is a high-purity bicyclic ether solvent used to solubilize difficult cosmetic actives and improve formulation flexibility in serums, lotions, and treatment systems. Its combination of water compatibility and significant solvency for organic molecules makes it particularly valuable in low-viscosity active concentrates.
Chemical & Technical Profile
| INCI / Identity | Dimethyl Isosorbide |
|---|---|
| CAS No. | 5306-85-4 |
| Molecular Formula | C8H14O4 |
| Molecular Weight | 174.20 g/mol |
| Physical Form | Clear colorless liquid |
| Solubility | Miscible with water and many organic solvents; strong co-solvent behavior |
| Functional Category | High-polarity cosmetic solvent / active carrier |
Mechanism of Action / Technical Function
DMI functions through solvent interactions rather than biological activity. The rigid isosorbide-derived structure contains two ether groups capable of accepting hydrogen bonds while retaining an organic carbon framework, producing high polarity without conventional alcohol volatility. This allows it to increase apparent solubility and modify partitioning of selected lipophilic or crystalline actives.
Formulation Guidelines
Use as part of the water/solvent phase or as a pre-solvent for the active. Conduct solubility screening at actual formulation temperature and after water dilution because an active can dissolve in neat DMI and precipitate when the concentrate is added to the final aqueous system. DMI can also alter polymer hydration and preservative partitioning, so add it before final rheology optimization.
Compatibility & Stability
Monitor clarity, precipitation, viscosity, odor, and package compatibility. Solvent-rich systems can extract components from elastomers or change adhesive performance in labels. Low-temperature testing is essential for marginal solubility systems.
R&D, Scale-Up & Quality Control
For Dimethyl Isosorbide (DMI), incoming and in-process QC should control DMI identity, clarity, odor, and active-solvent capacity. Pilot transfer should lock pre-solvent ratio, dilution sequence into water, and final polymer/preservative adjustment, because these variables directly influence reproducibility. Release the formulation only after the target active remains dissolved through low-temperature storage without package extraction effects.
Packaging, Shipping & Storage
Supplied in a tightly sealed liquid container. Store cool, protected from contamination, direct light, and excessive heat.
Estimated Delivery: 10–15 Business Days
Applications
Active serums, solvent concentrates, emulsions, retinoid systems, brightening formulas, anhydrous/aqueous hybrids, and specialty treatment products.
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