Description
Description
Pterostilbene is a naturally occurring dimethoxylated stilbene structurally related to resveratrol. Replacement of two phenolic hydroxyl groups with methoxy groups increases lipophilicity and changes redox and partitioning behavior, making pterostilbene attractive for advanced antioxidant systems that can accommodate a low-water-solubility active.
Chemical & Technical Profile
| INCI / Identity | Pterostilbene |
|---|---|
| CAS No. | 537-42-8 |
| Molecular Formula | C16H16O3 |
| Molecular Weight | 256.30 g/mol |
| Physical Form | White to off-white crystalline powder |
| Solubility | Very low water solubility; soluble in alcohols and selected organic/lipid carriers |
| Functional Category | Dimethoxylated stilbene antioxidant |
Mechanism of Action / Technical Function
The molecule retains a phenolic hydroxyl group and conjugated stilbene system capable of radical-stabilizing redox chemistry. Its increased lipophilicity supports partitioning into nonaqueous environments, while experimental research has examined modulation of oxidative-stress and inflammatory signaling. Cosmetic positioning should emphasize antioxidant and skin-conditioning functionality rather than therapeutic pathways.
Formulation Guidelines
Pre-solubilize in ethanol, glycols, suitable esters, oils, or another validated carrier before addition. Do not add dry powder directly to a finished water-based serum. In emulsions, incorporate via the oil or solvent phase and evaluate distribution after cooling. Low-temperature stability is essential because marginally soluble systems can crystallize after manufacture. Avoid prolonged light exposure and strong oxidizing environments.
Compatibility & Stability
Monitor crystallization, precipitation, color, odor, and active-content retention. The stilbene double bond and phenolic system remain sensitive to photochemical and oxidative change. Use opaque or UV-limiting packaging where possible.
R&D, Scale-Up & Quality Control
R&D qualification of Pterostilbene should include identity, solvent clarity, color, and recrystallization. For manufacturing scale-up, define and control pterostilbene pre-solubilization, carrier dilution, and cooling profile rather than transferring only the ingredient percentages. The batch is technically acceptable when no crystals or photochemical color changes emerge after low-temperature/light challenges. Compare clear and light-exposed retained samples.
Packaging, Shipping & Storage
Supplied in a sealed aluminum pouch. Store tightly closed, cool, dry, and protected from direct light, oxygen, and prolonged heat.
Applications
Antioxidant serums, facial oils, emulsions, eye-area systems, premium age-support products, and multi-polyphenol formulations.
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