Description
Description
Ceramide NP Powder is a high-value sphingolipid used to reconstruct skin-like lipid architecture in moisturizers and barrier-support systems. Its technical role is distinct from conventional emollients: ceramide is intended to participate in organized intercellular lipid structures rather than merely forming an oily surface layer.
Chemical & Technical Profile
| INCI / Identity | Ceramide NP |
|---|---|
| CAS No. | 100403-19-8 |
| Molecular Formula | Long-chain sphingolipid |
| Molecular Weight | Grade-dependent |
| Physical Form | White to off-white powder |
| Solubility | Lipophilic; practically insoluble in water |
| Functional Category | Skin-identical barrier lipid |
Mechanism of Action / Technical Function
The molecule contains a fatty-acid amide linked to a phytosphingosine-type base, giving strong hydrogen-bonding capacity and high chain ordering. In stratum-corneum-like lipid mixtures, Ceramide NP cooperates with cholesterol and free fatty acids to form lamellar phases with low permeability. The same structural principles guide high-performance cosmetic barrier formulations.
Formulation Guidelines
Use a compatible lipid carrier and controlled heating to achieve uniform incorporation. Pure or concentrated Ceramide NP should not be stirred directly into the water phase. In emulsions, ensure that the oil phase and emulsifier system can maintain the lipid during cooling. Excessive ceramide without appropriate co-lipids can crystallize and create graininess. Small-scale polarized-light or microscopy evaluation is valuable during development.
Compatibility & Stability
Monitor grain formation, phase separation, viscosity, melting behavior, and low-temperature stability. A visually smooth fresh batch can develop crystals after weeks of storage if the lipid phase is supersaturated. Packaging should protect from repeated heat cycling.
R&D, Scale-Up & Quality Control
R&D qualification of Ceramide NP Powder should include Ceramide NP identity, crystal behavior, lipid-phase clarity, and graininess. For manufacturing scale-up, define and control ceramide carrier selection, melting profile, co-lipid balance, and controlled cooling rather than transferring only the ingredient percentages. The batch is technically acceptable when the barrier emulsion remains smooth and free of recrystallized ceramide domains.
Packaging, Shipping & Storage
Supplied in a sealed aluminum pouch. Store tightly closed, cool, dry, and protected from humidity and heat.
Applications
Barrier moisturizers, rich creams, eye products, sensitive-skin emulsions, dry-skin systems, and lamellar barrier formulations.
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