Description
Description
Climbazole is an imidazole-derived cosmetic active used internationally in scalp-care and scalp-comfort systems. Its low intrinsic water solubility requires deliberate solvent and surfactant design, but the molecule is attractive in shampoos and scalp treatments because it targets fungal organisms associated with dandruff ecology.
Chemical & Technical Profile
| INCI / Identity | Climbazole |
|---|---|
| CAS No. | 38083-17-9 |
| Molecular Formula | C15H17ClN2O2 |
| Molecular Weight | 292.76 g/mol |
| Physical Form | White crystalline powder |
| Solubility | Low water solubility; soluble in suitable alcohols, glycols, surfactant systems, and organic carriers |
| Functional Category | Scalp-care cosmetic active |
Mechanism of Action / Technical Function
Climbazole inhibits fungal sterol biosynthesis by interfering with cytochrome-P450-dependent 14α-demethylation steps in the ergosterol pathway. Depletion of ergosterol alters membrane structure and permeability in susceptible fungi. This biochemical mechanism explains why formulation performance depends not only on concentration but also on solubilization, deposition, and contact with the scalp surface.
Formulation Guidelines
Pre-solubilize in a compatible solvent, glycol, or surfactant concentrate before addition to the main batch. Do not expect the crystalline powder to dissolve directly in water. In clear shampoos, fragrance, electrolytes, and surfactant composition can shift solubility; conduct cloud-point and low-temperature testing after the complete formula is assembled. Incorporate at controlled temperature and avoid local supersaturation. Evaluate deposition and rinse profile in performance development.
Compatibility & Stability
Monitor precipitation, haze, color, pH, viscosity, and crystal formation. Low-temperature storage is particularly useful for revealing marginal solubility. The active does not replace the preservative system.
R&D, Scale-Up & Quality Control
For Climbazole Powder, incoming and in-process QC should control active dissolution, pH, clarity, and crystal formation. Pilot transfer should lock the climbazole solvent premix, surfactant/fragrance addition order, and final salt adjustment, because these variables directly influence reproducibility.
Packaging, Shipping & Storage
Supplied in a sealed aluminum pouch. Store tightly closed, cool, dry, and protected from light and heat. Avoid moisture contamination after opening.
Estimated Delivery: 10–15 Business Days
Applications
Scalp shampoos, conditioners, scalp tonics, cleansing systems, rinse-off treatments, and professional hair-care formulations.
Regulatory Note
In the United States, finished-product dandruff treatment claims are regulated separately from ordinary cosmetic claims. Formulators should establish claim eligibility and active-ingredient status for the intended market before commercialization.
Reviews
There are no reviews yet.